/dɪ'spaɪt; dɪ`spaɪt/
prep without being affected by (the factors mentioned) 尽管; 不管; 不顾
*They had a wonderful holiday, despite the bad weather. 尽管天气不好, 他们的假日还是过得极为愉快.
* Despite wanting to see him again, she refused to reply to his letters. 她尽管很想再见到他, 但却不愿给他回信.
* Despite what others say, I think he's a very nice chap. 不管别人怎么说, 我仍认为他这个人很好. Cf 参看 in spite of (spite).

prep
[Date: 1200-1300; Language: Old French;Origin: despit 'spite', from Latin despectus, from despicere; DESPISE]
used to say that something happens or is true even though something else might have prevented it
= in spite of
　Despite all our efforts to save the school, the authorities decided to close it.
despite the fact (that)
　She went to Spain despite the fact that her doctor had told her to rest.
despite yourself
if you do something despite yourself, you do it although you did not intend to
　Liz realized that, despite herself, she cared about Edward.